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Armistice Capital, LLC
Ghost Tree Capital, LLC
Sivik Global Healthcare LLC
Lilly Endowment Inc
Pura Vida Investments, LLC
First Light Asset Management, LLC
Avoro Capital Advisors LLC
Acuta Capital Partners, LLC
Pfm Health Sciences, Lp
Alethea Capital Management, LLC
Great Point Partners LLC
Krensavage Asset Management, LLC
Sector Gamma As
Aviva Holdings Ltd.
Lumina Fund Management LLC
Dafna Capital Management LLC
Tamarack Advisers, Lp
Rhenman & Partners Asset Management Ab
Flagship Pioneering Inc.
Suvretta Capital Management, LLC
Foresite Capital Management Iii, LLC
Healthcor Management, l.p.
Ecor1 Capital, LLC
Bvf Inc/il
Bellevue Group Ag
Sarissa Capital Management Lp
Sio Capital Management, LLC
Robert Wood Johnson Foundation
Vivo Capital, LLC
Bruce & Co., Inc.
Rtw Investments, Lp
Palo Alto Investors Lp
Boxer Capital, LLC
Endurant Capital Management Lp
Tekla Capital Management LLC
Sphera Funds Management Ltd.
Highvista Strategies LLC
Opaleye Management Inc.
Orbimed Advisors LLC
Neumann Capital Management, LLC
Rock Springs Capital Management Lp
Jet Capital Investors L P
New Leaf Venture Partners, l.l.c.
Baker Bros. Advisors Lp
Northwestern University
International Biotechnology Trust Plc
Matisse Capital
Sectoral Asset Management Inc
Oracle Investment Management Inc
New Vernon Capital Holdings Ii LLC